[Effect of glucagon on changes of carbohydrate metabolism in experimental hemorrhagic shock]

The behaviour of venous blood glucose, lactate and pyruvate concentration was tested in experimental shock, caused by bleeding in rabbits. The animals of one group were retransfused after 1.5 hours hypotension of 40 mm Hg. The animals of another group were left with a total blood removal of 2% body weight. We found a significantly higher blood sugar reaction in the longer surviving animals of the group in comparison to the ones, which died early. A single or repeated intravenous application of 70/1000 mg glucagon was not followed by a statistically visible change of blood sugar-, lactate- and pyruvate values in shock versus the control group. In spite of pronounced hypovolemia 20 of 22 animals, treated with glucagon, showed an increase of blood pressure by 20 mm Hg and of cardial frequency, especially after the first injection over a period of 10 minutes with decreasing tendency in the further course of shock.