[Immunologic studies in patients with clinical human albumin incompatibility]

17 cases of clinical incompatibility reactions due to human serum albumin were examined. The reactions consisted of tachycardia, fever, exanthema and hypotension. Regarding the onset of time, "early" and "late" reactions were distinguished. Pollution of the administered albumin batches as etiologic factor was excluded. The results of immunodiffusion, antigen elimination and skin tests suggest a pathogenetic influence of immunological reactions. The application of further purified albumin solutions might reduce the frequency of incompatibility reactions.