Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Embryonic stem cells share immune-privileged features relevant for tolerance induction.

Fred Fändrich1, Bettina Dresske, Michael Bader

  • 1Department of General and Thoracic Surgery, University of Kiel, Arnold-Heller-Strasse 7, 24105 Kiel, Germany. ffaendrich@surgery.uni-kiel.de

Journal of Molecular Medicine (Berlin, Germany)
|June 20, 2002
PubMed
Summary

Inducing graft tolerance, where the body accepts transplanted organs without lifelong immunosuppression, is crucial for transplant recipients. Research is exploring maternofetal immunobiology for insights into preventing transplant rejection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Secretory products from regulatory macrophages modulate senescence in human endothelial cells: implications for cardiovascular aging and diseases.

BMC cardiovascular disorders·2026
Same author

Surgical closure of congenital portosystemic shunts in children: A modified classification for transitioning to minimally invasive repair.

Journal of pediatric surgery·2026
Same author

Assessment of Donor-Specific Human Leukocyte Antigen Antibodies Following Pediatric Liver Transplantation: Predictors, Protectors, and Clinical Relevance.

Clinical transplantation·2025
Same author

[Amatoxin poisoning with acute liver failure].

Chirurgie (Heidelberg, Germany)·2025
Same author

Transcriptomic characterization of GMP-compliant regulatory macrophages (TRI-001) under inflammatory and hypoxic conditions: a comparative analysis across macrophage subtypes.

Journal of translational medicine·2025
Same author

Effects of temporal IFNγ exposure on macrophage phenotype and secretory profile: exploring GMP-Compliant production of a novel subtype of regulatory macrophages (Mreg<sub>IFNγ0</sub>) for potential cell therapeutic applications.

Journal of translational medicine·2024

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Reproductive Immunology

Background:

  • Continuous immunosuppression prevents graft rejection but increases risks of infection and cancer.
  • Developing strategies to induce graft tolerance is a key goal in transplantation medicine.
  • Understanding how the mother tolerates paternal antigens in the fetus offers potential tolerance mechanisms.

Purpose of the Study:

  • To review the challenges of long-term immunosuppression in organ transplantation.
  • To highlight the importance of inducing specific immune tolerance to donor alloantigens.
  • To explore the potential of maternofetal immunobiology in developing novel tolerance strategies.

Main Methods:

  • Review of existing literature on transplantation immunology and maternofetal tolerance.

Related Experiment Videos

  • Analysis of major histocompatibility antigens and their role in allograft rejection.
  • Examination of immune privilege mechanisms in prenatal development.

    • Main Results:

    • Life-long immunosuppression poses significant risks to transplant recipients.
    • Graft acceptance without immunosuppression requires inducing tolerance to donor antigens.
    • Maternofetal tolerance mechanisms remain incompletely understood but offer promising avenues.

    Conclusions:

    • Innovative strategies are needed to overcome the limitations of current immunosuppressive therapies.
    • Further research into maternofetal immunobiology may provide critical insights for inducing transplant tolerance.
    • Achieving graft tolerance could revolutionize organ transplantation by eliminating long-term immunosuppression risks.