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[Arteriosclerosis: morbid anatomy (author's transl)]
Insights
Pathology, a variant of physiology, reveals arteriosclerosis stems from disturbed humor flow. Breaking the cluster of risk factors is key for future arteriosclerosis treatment.
Area of Science:
- Cardiovascular Science
- Pathophysiology
Context:
- Arteriosclerosis pathogenesis involves arterial wall permeability and humor flow disturbances.
- The author's "Perfusion theory" posits a basic form of arteriosclerosis arising from lifelong humor flow issues.
Purpose:
- To analyze postmortem data and establish connections between risk factors and arteriosclerosis.
- To re-evaluate the role of certain risk factors, such as smoking, in arteriosclerosis development.
Summary:
- Pathology is presented as a variant of physiology, with arteriosclerosis arising from disturbed "humor" flow (Perfusion theory).
- Analysis of postmortem material confirmed links between some risk factors and arteriosclerosis.
- The connection between smoking and arteriosclerosis was questioned, necessitating further investigation.
Impact:
- Highlights the need to break down risk factor clusters for effective arteriosclerosis treatment.
- Suggests a shift in understanding arteriosclerosis etiology and management strategies.
Abstract:
Pathology is a variant of physiology with obstacles. No arterial wall is absolutely impermeable. The basic form of arteriosclerosis results from a disturbance of the lifelong flow of humors ab intima in adventitiam et ex centro in peripheriam (author's "Perfusion theory"). Special forms develop from this basic form. Analysis of postmortem material with special reference to the so-called risk factors allowed us to establish connections between some of these factors and arteriosclerosis, while some other connections, e.g. with smoking, were called in question. It is pointed out that prospective treatment of arteriosclerosis will begin only when the cluster of risk factors can be broken down.