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Serum complement (C3 and C4) levels in the Malaysian adult population
Asian Journal of Infectious Diseases
|June 1, 1979
Insights
Serum complement component 3 (C3) and C4 levels were measured in 236 adults across three racial groups. Results showed no significant differences based on sex or race, with values comparable to Western norms.
Area of Science:
- Immunology
- Biochemistry
- Clinical Chemistry
Background:
- Complement system proteins C3 and C4 are crucial in immune response.
- Establishing reference ranges for these proteins is vital for clinical diagnostics.
- Inter-population variations in complement levels require investigation.
Purpose of the Study:
- To determine normal serum C3 and C4 levels in a multi-racial adult population.
- To investigate potential variations in C3 and C4 levels related to sex and race.
- To compare findings with established Western reference ranges.
Main Methods:
- Serum samples were collected from 236 healthy adults representing three distinct racial groups.
- Single radial immunodiffusion technique was employed for quantitative analysis of C3 and C4.
- Statistical analysis was performed to assess variations based on sex and race.
Main Results:
- Serum C3 levels ranged from 47 to 119 mg/dl (mean +/- 2SD).
- Serum C4 levels ranged from 16 to 66 ml/dl (mean +/- 2SD).
- No statistically significant differences were observed in C3 or C4 levels concerning sex or racial group.
Conclusions:
- The study establishes reference ranges for serum C3 and C4 in the studied population.
- Findings suggest that normal serum C3 and C4 levels are consistent across different sexes and races in this cohort.
- The results support the comparability of these complement levels with those reported in Western populations.
Abstract:
Serum C3 and C4 values were determined in 236 normal adults of three racial groups, using the single radial immunodiffusion techniques. The C3 levels varied from 47 to 119 mg/dl and C4 levels from 16 to 66 ml/dl (mean +/- 2SD). The values were found to be comparable to the normals reported in some Western series. No significant differences in the levels related to sex and race were found.