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[Interstitial nephritis induced by mesalazine].

Masaki Ohya1, Haruhisa Otani, Keigo Kimura

  • 1Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.

Nihon Jinzo Gakkai Shi
|June 21, 2002
PubMed
Summary

Mesalazine, a treatment for inflammatory bowel disease, can cause interstitial nephritis, a kidney condition. Early diagnosis and monitoring are crucial to prevent irreversible kidney damage.

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Area of Science:

  • Nephrology
  • Gastroenterology
  • Pharmacology

Background:

  • Mesalazine is a common treatment for inflammatory bowel disease (IBD).
  • Interstitial nephritis is a known potential side effect of mesalazine.
  • This report details the first case in Japan of mesalazine-induced interstitial nephritis.

Observation:

  • A 27-year-old woman with ulcerative colitis developed severe tubulo-interstitial nephritis after 12 months of mesalazine treatment.
  • Renal biopsy confirmed severe tubulo-interstitial nephritis.
  • Histological findings also suggested potential glomerular lesions with IgM and C3 deposition.

Findings:

  • Mesalazine treatment withdrawal and prednisolone administration led to a gradual decrease in serum creatinine levels, stabilizing at 2.8 mg/dl.

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  • Despite treatment, permanent renal impairment may occur if diagnosis is delayed.
  • The study highlights the possibility of mesalazine-induced glomerular lesions.

    • Implications:

    • Intensive renal function monitoring is essential for patients treated with mesalazine.
    • Delayed diagnosis of mesalazine-induced interstitial nephritis can lead to irreversible renal failure.
    • Further research into mesalazine's potential to induce glomerular lesions is warranted.