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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Coronary revascularization improves long-term prognosis in diabetic and nondiabetic end-stage renal disease
Jiro Aoki1, Yuji Ikari, Hiroyoshi Nakajima
1Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
Insights
Coronary revascularization significantly improves long-term survival for patients undergoing hemodialysis. Achieving complete revascularization is key for better outcomes in both diabetic and non-diabetic patients.
Area of Science:
- Cardiology
- Nephrology
- Vascular Surgery
Background:
- Patients on maintenance hemodialysis often have coronary artery disease.
- Coronary revascularization aims to improve prognosis in this high-risk population.
Purpose of the Study:
- To evaluate the long-term impact of coronary revascularization on survival in hemodialysis patients.
- To identify predictors of survival following revascularization in this cohort.
Main Methods:
- Retrospective analysis of 80 hemodialysis patients who underwent coronary revascularization (bypass surgery, angioplasty, or both) between 1983-1999.
- Comparison of outcomes between diabetic and non-diabetic patients.
- Survival analysis from initiation of hemodialysis and from date of revascularization.
Main Results:
- Complete revascularization was achieved in 75% of diabetic and 83% of non-diabetic patients.
- Five-year survival rates from hemodialysis initiation were 79% (diabetic) and 96% (non-diabetic), exceeding international benchmarks.
- Age and complete revascularization were predictors of survival; diabetes was not a significant predictor.
Conclusions:
- Coronary revascularization enhances long-term survival in hemodialysis patients.
- Complete revascularization is associated with improved outcomes, irrespective of diabetic status.
Abstract:
To test the hypothesis that coronary revascularization improves long-term prognosis in patients with hemodialysis, 80 of 121 patients (66%) on maintenance hemodialysis who had undergone initial coronary angiography had bypass surgery, catheter angioplasty, or both between 1983 and 1999. Multivessel disease was more frequent (p=0.01) and the duration of hemodialysis therapy was shorter (p=0.01) in patients with diabetes (n=61), than in nondiabetic patients (n=60). Of the patients who underwent revascularization, complete revascularization was achieved in 75% of those with diabetic nephropathy (30/40) and 83% in a similar number of nondiabetic patients (33/40). The 5-year survival rate from initiation of hemodialysis was 79% in diabetic and 96% in non-diabetic patients (p<0.01), exceeding published Japanese (53% vs 70%) and US (26% vs 60%) survival rates. When survival was studied from the date of revascularization, predictors of outcome were age and achievement of complete revascularization. Surprisingly, diabetes was not a predictor of survival outcome. Complete revascularization improves long-term survival in both diabetic and nondiabetic patients.
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