Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developments in endovascular therapy for acute ischemic stroke.

Andrew J Ringer1, Thomas A Tomsick

  • 1The Neuroscience Institute, Department of Neurosurgery, University of Cincinnati College of Medicine, OH 45267-0515, USA. ringeraj@ucbeth.san.uc.edu

Neurological Research
|June 21, 2002
PubMed
Summary

Intravenous thrombolysis with tissue-type plasminogen activator (t-PA) is the first effective acute ischemic stroke therapy, but its limited window and efficacy necessitate further advancements. New treatments like intra-arterial thrombolysis offer hope for more patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DWI Positivity in Mild, Nondisabling Acute Cerebral Ischemia: Data From the PRISMS Trial.

Stroke (Hoboken, N.J.)·2026
Same author

Extensive ischemic change on stroke presentation is uncommon: A population-based study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2025
Same author

Assessing Population-Based Radiological Brain Health in Stroke Epidemiology: Rationale and Design.

Cerebrovascular diseases (Basel, Switzerland)·2025
Same author

Impact of duration of dual anti-platelet therapy on risk of complications after stent-assisted coiling of unruptured aneurysms.

Journal of neurointerventional surgery·2024
Same author

North American multicenter experience with the Flow Redirection Endoluminal Device in the treatment of intracranial aneurysms.

Journal of neurosurgery·2022
Same author

Radiographic and clinical outcomes with particle or liquid embolic agents for middle meningeal artery embolization of nonacute subdural hematomas.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2022

Area of Science:

  • Neurology
  • Emergency Medicine
  • Cardiovascular Research

Background:

  • Acute ischemic stroke treatment historically lacked efficacy, with animal models failing to translate to clinical success.
  • Rapid reperfusion of ischemic brain tissue is crucial but limited by hemorrhage risks associated with clot-dissolving agents.
  • Risk factor modification and rehabilitation were primary stroke management strategies before effective acute therapies.

Purpose of the Study:

  • To review the evolution of acute ischemic stroke treatment, highlighting the impact of intravenous tissue-type plasminogen activator (t-PA).
  • To discuss the limitations of current thrombolytic therapies, including efficacy and treatment windows.
  • To explore promising advancements in acute ischemic stroke management.

Main Methods:

Related Experiment Videos

  • Review of the National Institute of Neurological Disorders and Stroke (NINDS) trial of intravenous t-PA.
  • Analysis of the limitations and patient populations benefiting from intravenous thrombolysis.
  • Examination of emerging treatment modalities and diagnostic technologies for acute ischemic stroke.

Main Results:

  • The 1995 NINDS trial established intravenous t-PA as the first proven effective therapy for acute ischemic stroke, applicable across age groups.
  • Intravenous thrombolysis remains ineffective for many patients and is unavailable to those outside the 3-hour window.
  • Newer approaches such as intra-arterial and mechanical thrombolysis, combination therapies, and advanced imaging show potential for broader patient benefit.

Conclusions:

  • Intravenous t-PA revolutionized acute ischemic stroke care, but its limitations persist.
  • Further research and development are essential to improve treatment efficacy and accessibility for acute ischemic stroke patients.
  • Advanced imaging and novel therapeutic strategies hold promise for expanding treatment options and improving outcomes in acute ischemic stroke.