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Updated: Aug 1, 2026
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Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant
Published on: September 7, 2016
Cellular fibronectin in failing dental implants
Jian Ma1, Timo Sorsa, Mauno Könönen
1Biomedicum Helsinki/Anatomy, University of Helsinki, Finland.
Summary
Failing dental implants show increased cellular fibronectin, unlike adult periodontitis which has decreased levels. This suggests different mechanisms in implant failure versus periodontal disease.
Area of Science:
- Oral biology
- Biomaterials science
- Periodontology
Background:
- Cellular fibronectin (c-Fn) degradation is linked to adult periodontitis.
- This suggests elastase-mediated breakdown of periodontal tissues.
- The role of c-Fn in failing dental implants is not well understood.
Purpose of the Study:
- To investigate cellular fibronectin (c-Fn) changes in failing dental implants.
- To compare these changes with those observed in adult periodontitis.
- To elucidate the pathomechanisms involved in dental implant failure.
Main Methods:
- Immunohistochemistry was used to identify c-Fn and its integrin receptors.
- Computerized image analysis quantified c-Fn staining.
- Comparisons were made between failing implants, periodontitis, and healthy controls.
Main Results:
- Cellular fibronectin was present in blood vessel walls, epithelial basement membranes, and fibroblasts.
- Failing dental implants showed increased c-Fn staining (median 26.5%).
- Adult periodontitis showed decreased c-Fn staining (median 5.5%) compared to controls (median 12.2%).
Conclusions:
- Failing dental implants exhibit increased cellular fibronectin deposition, likely due to titanium-induced synthesis.
- Adult periodontitis is characterized by c-Fn proteolysis and loss.
- The pathomechanisms underlying adult periodontitis and failing dental implants appear distinct.
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