Related Experiment Videos
One-step ethynylation of silyl enol ether with chlorosilylethyne
Mieko Arisawa1, Ryo Amemiya, Masahiko Yamaguchi
1Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Sendai 980-8578, Japan.
Organic Letters
|June 21, 2002
Abstract:
[reaction: see text] In the presence of GaCl(3), silyl enol ethers are ethynylated at the alpha-carbon atom with chlorotrimethylsilylethyne. This reaction can provide alpha-ethynylated aryl ketones possessing acidic alpha-protons without isomerization to conjugated allenyl ketones.