Progress in the Research of Plasminogen Activator Inhibitor Type-2

Plasminogen activator inhibitor type-2 (PAI-2) inhibits urokinase type plasminogen activator (u-PA) most specifically and high efficiently, following the mechanism of serine proteinase inhibitor (serpin) superfamily. PAI-2 plays a very important role in vivo there are, however, two conflicting views on the role of PAI-2 in cancer. Tissue-type plasminogen activator, vitronectin, transglutaminases, fibrin and many other molecules can interact with PAI-2. Regulation factors of PAI-2 gene expression includes many regulatory elements in the promoter region, a number of agonists and conditions of organism, etc., showing that PAI-2 gene is regulated by both positive and negative mechanisms.