White and black blood volumetric angiographic filtering: ellipsoidal scale-space approach

Prefiltering is a critical step in three-dimensional (3-D) segmentation of the blood vessel and its display (see the recent book by Suri et al.). This paper presents a scale-space approach for filtering the white blood and black blood angiographic volumes and its implementation issues. The raw MR angiographic volume is first converted to isotropic volume followed by 3-D higher order separable Gaussian derivative convolution with known scales to generate edge volume. The edge volume is then run by the directional processor at each voxel where the eigenvalues of the 3-D ellipsoid are computed. The vessel score per voxel is then estimated based on these three eigenvalues which suppress the nonvasculature and background structures yielding the filtered volume. The filtered volume is ray-cast to generate the maximum intensity projection images for display. The performance of the system is evaluated by computing the mean, variance, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) images. The system is run over 20 patient studies from different areas of the body such as the brain, abdomen, kidney, knee, and ankle. The computer program takes around 150 s of processing time per study for a data size of 512 x 512 x 194, which includes the complete performance evaluation. We also compare our strategy with the recently published MR filtering algorithms by Alexander et al. and Sun et al.