Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carbamazepine for cocaine dependence.

A R Lima1, M S Lima, B G Soares

  • 1Centro de Medicina Baseada em Evidências, Universidade Federal de Pelotas, Av. Duque de Caxias, 250, Pelotas, RS, Brazil, 96100. mslima@nutecnet.com.br

The Cochrane Database of Systematic Reviews
|June 22, 2002
PubMed
Summary

Carbamazepine (CBZ) did not show significant effectiveness in treating cocaine dependence, with no improvement in cocaine metabolite levels and only slight, non-significant anxiety score reductions. Higher side effect incidence was observed in the CBZ group.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Tinkering with care: Implementing extended-release buprenorphine depot treatment for opioid dependence.

The International journal on drug policy·2024
Same author

Rare Variant of Lateral Medullary Syndrome; Opalski Syndrome with Cerebellar Infarction.

Irish medical journal·2023
Same author

One-step laparoscopy-guided abomasopexy versus omentopexy via right flank laparotomy to treat left displaced abomasum in dairy cows, in relation to return of milk yield.

Veterinary journal (London, England : 1997)·2023
Same author

Extreme eutrophication and salinisation in the Coorong estuarine-lagoon ecosystem of Australia's largest river basin (Murray-Darling).

Marine pollution bulletin·2023
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022

Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Trials

Background:

  • Cocaine dependence is a significant public health issue with severe medical, psychological, and social consequences.
  • Effective pharmacotherapy is crucial for cocaine dependence treatment within a broader therapeutic framework.
  • Carbamazepine (CBZ), an anticonvulsant, has been explored for cocaine dependence, but its efficacy remains unproven.

Purpose of the Study:

  • To systematically evaluate the effectiveness of carbamazepine (CBZ) in treating cocaine dependence.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (Cochrane, MEDLINE, EMBASE, PsycLIT, etc.) and other sources for randomized controlled trials (RCTs).
  • Inclusion criteria focused on RCTs comparing carbamazepine versus placebo for cocaine dependence, including trials with co-occurring opiate dependence.

Related Experiment Videos

  • Data extraction included Odds Ratios and weighted mean difference, with sensitivity analyses for dropouts and adherence to intention-to-treat principles.

    • Main Results:

    • Five RCTs involving 455 participants were analyzed, revealing no significant difference in positive urine cocaine metabolite tests between carbamazepine and placebo groups.
    • While carbamazepine showed a slight, non-statistically significant improvement in anxiety scores, dropout rates were high in both groups (up to 70% in placebo).
    • The incidence of side effects was significantly higher in the carbamazepine group compared to placebo.

    Conclusions:

    • Current evidence does not support the clinical use of carbamazepine for treating cocaine dependence.
    • Further large-scale randomized trials are warranted, but should prioritize medications with more promising preliminary evidence.