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Viral RNA-polymerases -- a predicted 2'-O-ribose methyltransferase domain shared by all Mononegavirales
François Ferron1, Sonia Longhi, Bernard Henrissat
1Architecture et Fonction des Macromolécules Biologiques, UMR 6098, CNRS, and Universitées Aix-Marseille I and II, ESIL, 163, Avenue de Luminy, Case 925, F-13288 Marseille Cedex 9, France.
Trends in Biochemical Sciences
|June 22, 2002
Abstract:
The Mononegavirales virus group comprises several major human pathogens, including measles, rabies and Ebola viruses. This article reports a computational analysis of the C-terminal region of RNA-dependent RNA-polymerases from Mononegavirales. Using a combination of sequence similarity and threading analysis, a 2'-O-ribose methyltransferase domain was identified that is involved in the capping of viral mRNAs.