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AbrB is a regulator of the sigma(W) regulon in Bacillus subtilis
Qiang Qian1, Chien Y Lee, John D Helmann
1Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, 666 W. Baltimore St., Room 4-C-30, Baltimore, MD 21201, USA.
FEMS Microbiology Letters
|June 22, 2002
Abstract:
The Bacillus subtilis global regulator AbrB was found to negatively control expression of sigW and genes of the sigma(W) regulon. AbrB bound to DNA regions in the autoregulatory sigW promoter and to some, but not all, of the other sigma(W)-dependent promoters in B. subtilis. Defects in antibiotic resistance properties caused by spo0A mutations are at least partially correlated with AbrB repression of the sigma(W) regulon.