[Intranuclear particles in a patient with chronic aggressive hepatitis treated by immunosuppression]

After an acute HbsAg-positive transfusion hepatitis the patient--a 40 years old women--remained seropositive. Later a chronic aggressive hepatitis have developed, which could be evidenced by histological findings. On the electron microphage in the nucleus of liver cells ring-shaped particules 20--25 nm in diameter were revealed. They consisted of granula 2--3 nm in diameter. These particules are considered to represent so called virus-nuclei (core of the virus B of hepatitis) and to play a pathogenic role. These particules are commonly present and easily found. The great number of them--according to author's opinion--can be explained by the effect of immunosuppressive therapy.