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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

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Related Experiment Video

Updated: Jun 17, 2026

In vitro Functional Characterization of Mouse Colorectal Afferent Endings
14:09

In vitro Functional Characterization of Mouse Colorectal Afferent Endings

Published on: January 21, 2015

Visceral perception: inflammatory and non-inflammatory mediators.

L Bueno1, J Fioramonti

  • 1Department of Neurogastroenterology and Nutrition, Institut National de la Recherche Agronomique, Neurogastroenterology Unit INRA, 180 Chemin de Tournefeville, BP3 31931 Toulouse Cedex 9, France. lbueno@toulouse.inra.fr

Gut
|June 22, 2002
PubMed
Summary

Visceral hypersensitivity, a key cause of abdominal pain, involves inflammatory and non-inflammatory mediators. These mediators sensitize nerves and activate pain receptors, forming a crucial gut-brain signaling system.

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Area of Science:

  • Gastroenterology
  • Neuroscience
  • Pain Research

Background:

  • Visceral hypersensitivity is the primary mechanism underlying abdominal pain.
  • Inflammatory mediators are known to sensitize primary afferents and recruit silent nociceptors.

Purpose of the Study:

  • To explore the role of non-inflammatory mediators in triggering visceral pain.
  • To understand the alerting system involved in gastrointestinal responses to ingestion.

Main Methods:

  • Review of recent evidence on visceral pain mechanisms.
  • Analysis of the signaling pathways involved in visceral hypersensitivity.

Main Results:

  • Non-inflammatory mediators can also trigger visceral pain.
  • These mediators contribute to an alerting system for gastrointestinal regulation.

Conclusions:

  • Visceral pain involves both inflammatory and non-inflammatory mediators.
  • This pain signaling system alerts the central nervous system to correct digestive responses.