Jove
Visualize
Contact Us
  1. Home
  3. Identification Of Objective Pathological Prognostic Determinants And Models Of Prognosis In Dukes' B Colon Cancer.
  1. Home
  3. Identification Of Objective Pathological Prognostic Determinants And Models Of Prognosis In Dukes' B Colon Cancer.

Related Concept Videos

JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer.

V C Petersen1, K J Baxter, S B Love

  • 1Department of Histopathology and Cranfield Postgraduate Medical School in Gloucestershire, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK.

Gut
|June 22, 2002

View abstract on PubMed

Summary
This summary is machine-generated.

Identifying prognostic factors in Dukes

Related Experiment Videos

Area of Science:

  • Colorectal cancer research
  • Oncology
  • Pathology

Background:

  • Dukes' B colon carcinoma prognosis is difficult to determine.
  • Adjuvant chemotherapy efficacy for Dukes' B patients is unclear.
  • Need for objective pathological prognostic markers in colon cancer.

Purpose of the Study:

  • Assess pathological factors influencing prognosis in Dukes' B colon cancer.
  • Identify objective prognostic parameters for patient selection.
  • Inform treatment decisions for colon cancer patients.

Main Methods:

  • Prospective study of 268 Dukes' B colon cancer resections.
  • Meticulous pathological assessment of prognostic factors.
  • Comprehensive patient follow-up system utilized.

Main Results:

  • Four independent prognostic factors identified: peritoneal involvement, venous spread, surgical margin involvement, and perforation.
  • Multivariate analysis confirmed significance of these factors.
  • A cumulative scoring system combining these factors created prognostic groups.

Conclusions:

  • Cumulative prognostic index stratifies Dukes' B colon cancer patients.
  • Objective patient selection for adjuvant therapy is enabled.
  • Facilitates patient stratification in clinical trials for colon cancer.