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Related Experiment Videos

Multifocal coronary plaque instability.

James A Goldstein1

  • 1Cardiology Division, William Beaumont Hospital, Royal Oak, MI 48073, USA.

Progress in Cardiovascular Diseases
|June 22, 2002
PubMed
Summary
This summary is machine-generated.

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Patients with acute coronary syndromes often have multiple complex plaques, indicating plaque instability is a systemic issue affecting the entire cardiovascular system, not just local areas.

Area of Science:

  • Cardiovascular Medicine
  • Pathophysiology
  • Angiography

Background:

  • Acute coronary syndromes are frequently associated with multiple complex atherosclerotic plaques.
  • Angiography reveals widespread plaque burden in affected patients.
  • Necropsy studies correlate multiple complex plaques with plaque rupture and thrombosis.

Purpose of the Study:

  • To investigate the systemic nature of atherosclerotic plaque instability.
  • To determine if plaque instability in coronary and peripheral vessels occurs concurrently.
  • To support the concept of systemic pathophysiological processes driving plaque destabilization.

Main Methods:

  • Review of recent clinical observations and necropsy findings.
  • Correlation analysis between angiographic findings and post-mortem examinations.

Related Experiment Videos

  • Comparative assessment of plaque instability in coronary and peripheral vasculature.

    • Main Results:

    • Multiple complex plaques are common in patients with acute coronary syndromes.
    • Plaque instability is observed multifocally in both coronary and peripheral arteries.
    • Concomitant instability in coronary and peripheral vessels suggests a systemic process.

    Conclusions:

    • Atherosclerotic plaque instability is not a localized event.
    • Systemic pathophysiological processes contribute to widespread plaque destabilization.
    • Plaque instability reflects a systemic cardiovascular condition.