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[DNA analysis for the post genome-sequencing era].

Hideki Kambara¹

¹Central Research Laboratory, Hitachi, Ltd., Kokubunji 185-8601.

Rinsho Byori. the Japanese Journal of Clinical Pathology

|June 25, 2002

Summary

The post-genome era focuses on gene function discovery for medical and industrial applications. New DNA analysis technologies, including sequencing and SNP typing, have been developed to meet these needs.

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Area of Science:

Genomics and Molecular Biology
Biotechnology and Bioinformatics

Context:

The completion of the Human Genome Project marked the beginning of a new era in biological research.
Understanding gene function is crucial for advancements in medicine and various industries.

Purpose:

To review the historical development and technological advancements in DNA analysis.
To highlight key technologies enabling gene function clarification and genetic diversity analysis.

Summary:

This review covers the evolution of DNA analysis technologies from early projects like the Wada project to the Human Genome Project.
It details recent innovations such as capillary gel array DNA sequencers, DNA chips, bead probe arrays, pyrosequencing, and BAMPER for SNP typing.

Impact:

Accelerated progress in understanding gene function and human genetic diversity.
Enabled the development of new diagnostic tools and biotechnological applications.

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