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[Diaphragmatic hernia from 1961 to 2000--incidence, prenatal diagnosis and prevalence according to maternal age]
Insights
Diaphragmatic hernia occurred in 1321 infants in the Czech Republic between 1961-2000. Advanced maternal age, particularly 38 years or older, showed a higher risk for this birth defect.
Area of Science:
- Medical Science
- Epidemiology
- Neonatal Health
Context:
- Diaphragmatic hernia is a serious congenital anomaly.
- Understanding its incidence and risk factors is crucial for public health.
- This study examines trends in the Czech Republic over four decades.
Purpose:
- To present the incidence of diaphragmatic hernia in the Czech Republic from 1961 to 2000.
- To analyze the prevalence of diaphragmatic hernia in relation to maternal age.
- To identify potential risk factors associated with maternal age.
Summary:
- A retrospective demographic-epidemiological study analyzed 1321 cases of diaphragmatic hernia recorded in the Czech Republic between 1961 and 2000.
- The mean incidence was 2.32 per 10,000 live births, including prenatally diagnosed cases and terminations.
- A significantly higher risk was observed in fetuses of mothers aged 38 and 42 years or older compared to the population average.
Impact:
- Provides long-term epidemiological data on diaphragmatic hernia incidence.
- Highlights a potential association between advanced maternal age and increased risk.
- Informs prenatal counseling and risk assessment for pregnant women.
Objective:
Presentation of diaphragmatic hernia in the CR in 1961-2000. Analysis of prevalence of these defects in different groups by maternal age.
Design:
Retrospective demographic-epidemiological study.
Setting:
Institute for the Care of Mother and Child, Prague.
Methods:
The authors used data from nationwide registers of birth defects in neonates kept in the Institute of Health Information and Statistics of the CR during 1995-2000. Epidemiological analysis of the incidence of diaphragmatic hernia in the CR during 1961-2000 in newborn infants. Mathematical statistical analysis of prevalence of these defects by maternal age using the method of 95% confidence interval of probability.
Results:
In the CR during 1961-2000 1321 cases of diaphragmatic hernia were recorded. The mean incidence of this defect during the entire period was 2.32 per 10,000 live born infants incl. prenatally diagnosed cases and terminated pregnancies. Including those it was 2.37 per 10,000 live born infants.
Conclusion:
The authors elaborated the mean incidence during the investigation period and in individual years in born children as well as prenatally diagnosed cases. Also an analysis of the prevalence of these defects by maternal age was made using the method of 95% confidence interval. The authors found a significantly higher risk of development of this defect in foetuses of women aged 38, 42 years or older as compared with the population average. However an unequiwocally increased risk associated with more advanced age was neither confirmed nor ruled out.
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