Related Experiment Video
Updated: Sep 6, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Published on: October 3, 2012
Increased expression and redistribution of the antiapoptotic molecule Bcl-xL in Parkinson's disease
Andreas Hartmann1, Annick Mouatt-Prigent, Miquel Vila
1INSERM U 289, Hôpital de la Salpêtrière, 75013 Paris, France.
Abstract:
In the present study, we tried to clarify the potentially protective role of Bcl-x(L), an anti-apoptotic member of the Bcl-2 family of proteins, in Parkinson's disease (PD). Using in situ hybridization on human postmortem mesencephalon sections, we show that in PD patients Bcl-x(L) mRNA expression per dopaminergic neuron was almost double that of controls. We also show that, ultrastructurally, this effect may be mediated by a redistribution of Bcl-x(L) from the cytosol to the outer mitochondrial membrane.
More Related Videos
Related Concept Videos
Neural Regulation
The Intrinsic Apoptotic Pathway
Parkinson's Disease: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology

