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Updated: Sep 27, 2026
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
Does local hyperthermia affect metastasis of a human prostate carcinoma grown in athymic nude mice?
1Department of Urology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. surge04@post.tau.ac.il
Primary Objective:
This study investigated whether local hyperthermia increases metastasis of prostate carcinoma xenografts in athymic nude mice.
Research Design And Methods:
Human prostate carcinoma cells (1-LN-PC-3-1A) were injected into the animal's thigh. Mice were randomly divided into those treated with local hyperthermia (43 degrees C for 45 min, tumour volume 100 or 200 mm(3)) and untreated controls, and sacrificed when the tumour volume reached 500 mm(3).
Main Outcomes And Results:
Histological evaluation (hematoxylin and eosin staining) of lymph nodes showed metastases in 20/21 hyperthermia-treated and 17/21 control mice. Lymph node involvement, tumour weight at sacrifice, and tumour growth rate were not significantly different between groups.
Conclusion:
Single local hyperthermia treatment had no effect on lymph node metastatic spread in this model.
