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Updated: Jul 12, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 28, 2010
Preferential host switching by primate lentiviruses can account for phylogenetic similarity with the primate
M A Charleston1, D L Robertson
1Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK. michael.charleston@zoo.ox.ac.uk
Abstract:
Primate lentiviruses (PLV) from closely related primate species have been observed to be more closely related to each other than to PLV from more distantly related primate species. The current explanation for this observation is the codivergence hypothesis; that is, the divergence of a virus lineage results from the divergence of the host lineage. We show that, alternatively, frequent cross-species transmission of PLV, coupled with a tendency for more closely related primate species to exchange viruses "successfully," can result in apparent codivergence. This host-switching hypothesis reconciles several puzzling observations related to the evolution of PLV.
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