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Identification of susceptibility genes for complex metabolic diseases
Clifton Bogardus1, Leslie Baier, Paska Permana
1Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA. cbogardu@mail.nih.gov
Annals of the New York Academy of Sciences
|June 25, 2002
Abstract:
There are few successful attempts to identify genes for common, non-Mendelian diseases such as diabetes, hyperlipidemia, hypertension, etc. Such common disorders are typically both metabolically and genetically complex and the genetic technologies to identify their underlying susceptibility genes are still in their infancy. Nonetheless, genetic strategies have emerged that, when the technologies are fully developed, should allow similar success rates as for Mendelian diseases.