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Uncoupling proteins, leptin, and obesity: an updated review
1Département de Biochimie Médicale, C. M. U., 1211 Geneva 4, Switzerland. jean-paul.giacobino@medicine.unige.ch
Annals of the New York Academy of Sciences
|June 25, 2002
Abstract:
The hypothesis that the novel uncoupling protein UCP3 is thermogenic and/or thermoregulatory is discussed. In vitro, ex vivo, and in vivo models are presented. The beta(3)-adrenoceptors are crucial for the appearance of UCP1-expressing cells in the white adipose tissue. These cells might differ from classical brown adipocytes. Besides its well-known effect on brown adipose tissue UCP1, leptin might stimulate indirectly muscle UCP3 expression.