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Related Experiment Videos

The alkaline tide phenomenon.

Yaron Niv1, Gerald M Fraser

  • 1Department of Gastroenterology, Rabin Medical Center, Beilinson Campus and Sackler School of Medicine, University of Tel-Aviv, Israel. yniv@clalit.org.il

Journal of Clinical Gastroenterology
|June 25, 2002
PubMed
Summary
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Parietal cells secrete stomach acid using K+H+ ATPase. The resulting "alkaline tide" of bicarbonate efflux into blood can measure this acid secretion. This review summarizes published data.

Area of Science:

  • Physiology
  • Cell Biology
  • Gastroenterology

Background:

  • Parietal cells secrete gastric hydrochloric acid (HCl).
  • The K+H+ ATPase on the apical membrane drives proton secretion.
  • Intracellular homeostasis is maintained by basolateral transporters, including bicarbonate efflux.

Purpose of the Study:

  • To review published data on parietal cell function.
  • To highlight the role of the alkaline tide in measuring acid secretion.

Main Methods:

  • Review of existing scientific literature.

Main Results:

  • Parietal cells utilize K+H+ ATPase for acid secretion.
  • Carbonic anhydrase generates intracellular bicarbonate.

Related Experiment Videos

  • Bicarbonate efflux, the alkaline tide, occurs post-acid secretion.

    • Conclusions:

    • The alkaline tide is a measurable indicator of gastric acid secretion.
    • Understanding parietal cell physiology is crucial for studying gastric function.