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Effects of morphine on tumour growth
Mads Rasmussen1, Wei Zhu, Jan Tønnesen
1Department of Anaesthesia and Intensive Care, Aarhus University Hospital, 8000 Aarhus C, Denmark. mads@akhphd.au.dk
Neuro Endocrinology Letters
|June 25, 2002
Abstract:
Endogenous opiate alkaloids, such as morphine, and their peptide counterparts have been implicated in a wide variety of pharmacological and physiological functions. In addition to their use in the treatment of pain, opioids, appears to be important in the growth regulation of normal and neoplastic tissue. This review will focus on the influence of endogenous and exogenous opioids on tumour growth, with emphasis on immunoregulatory and antiproliferative mechanisms.