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Updated: Aug 8, 2026
Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
[Measuring beta-trace protein for detection of perilymph fistulas]
G Bachmann1, H Petereit, U Djenabi
1Øre-nese-hals-avdelingen, Universitetssykehuset i TromsØ, N-9038 Tromsø
Background:
beta-trace protein is an immunological marker for cerebrospinal fluid or inner ear fluids. We present two initial cases in which a beta-trace protein nephelometric assay provided immunological proof of perilymph in samples taken from the nasopharynx.
Patients And Methods:
Two cases are presented of an acute vestibulocochlear disorder following stapedotomy. Fluid samples, taken from the nasopharynx, were investigated using beta-trace protein laser nephelometry. The samples were collected using Merocel tamponades, which were left in place over night.
Results:
In both cases, the samples were positive for beta-trace protein. Tympanoscopy was performed and the oval window was closed. After tympanoscopy a partial recovery of the hearing impairment was observed.
Conclusion:
Using beta-trace protein, it seems to be possible to diagnose a perilymphatic fistula by noninvasive means.
