[Effect of desflurane on quantitative electroencephalogram and hemodynamics]

To evaluate the feasibility of monitoring depth of desflurane anesthesia by quantitative electroencephalogram(QEEG) and hemodynamics, eight ASA I-II patients were studied. Anesthesia was induced by propofol and vecuronium, after tracheal intubation and the lungs were ventilated with desflurane in oxygen. The results showed that desflurane significantly reduced bispectral index(BI), 95% spectral edge frequency(SEF) and median frequency(MF) in a negative linear dose-related manner. When the end-tidal desflurane concentration reached 1.5 MAC, mean artery pressure(MAP) was decreased significantly, and heart rate(HR) increased by 14.5% (but there was no statistic significance), compared with pre-anesthesia. The results suggest that QEEG can be used to monitor depth of desflurane anesthesia, but MAP and HR are not the ideal monitoring indices during desflurane anesthesia.