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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

[Use of ultrasonography to evaluate carotid atherosclerosis and hemodynamics]

P Fang1, Q Zhou, H Su

  • 1Department of Ultrasound, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.

Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
|June 26, 2002
PubMed

Insights

Carotid atherosclerosis (CAS) involves thickened common carotid intima-media thickness (IMT). Early-stage flat plaques at the carotid bifurcation did not significantly alter blood flow velocities or resistance indices.

Area of Science:

  • Vascular Ultrasound
  • Atherosclerosis Imaging
  • Carotid Artery Disease

Background:

  • Carotid atherosclerosis (CAS) is a significant risk factor for stroke.
  • Early detection and characterization of CAS are crucial for risk stratification.
  • Ultrasonography is a primary non-invasive tool for evaluating carotid artery disease.

Purpose of the Study:

  • To investigate the ultrasonographic characteristics of early carotid atherosclerosis.
  • To compare intima-media thickness (IMT) and hemodynamic parameters between CAS patients and healthy individuals.
  • To identify the typical morphology and location of early atheromatous plaques in the common carotid artery.

Main Methods:

  • One hundred and one cases diagnosed with carotid atherosclerosis (CAS) were included.
  • Ultrasonography was used to assess intima-media thickness (IMT) of the common carotid artery.
  • Parameters measured included peak systolic velocity (MAX), end-diastolic velocity (MIN), resistance index (RI), and vessel size.
  • Plaque morphology and location were documented.

Main Results:

  • The CAS group exhibited significantly thicker common carotid intima-media thickness (IMT) compared to the healthy group (P < 0.01).
  • No significant differences were observed in MAX, MIN, RI, or vessel size between the groups.
  • Atheromatous plaques were predominantly flat and located at the common carotid artery bifurcation, indicative of early pathological changes.

Conclusions:

  • Increased IMT is a key ultrasonographic marker of early carotid atherosclerosis.
  • Early, flat carotid plaques at the bifurcation may not significantly impact hemodynamic parameters like MAX, MIN, and RI.
  • Ultrasonography effectively identifies early atherosclerotic changes in the carotid arteries.

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