Related Experiment Video
Updated: Aug 17, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
Published on: June 7, 2013
[Study on the relationship between plasma endothelin nitric oxide concentration and renal hypertension and renal
1Department of Internal Medicine, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Objective:
To investigate the relationship between plasma endothelin(ET), nitric oxide(NO) levels and, renal hypertension and renal function.
Methods:
The plasma concentration of ET-1 was detected by immunofluorescence assay. The plasma concentration of NO was detected by biochemistry assay.
Results:
1. In renal disease patients, plasma concentration ET-1 was markedly elevated, and plasma concentration of NO was decreased, compared with the healthy subjects(P < 0.01). 2. Plasma concentration of ET-1 was markedly increased and plasma concentration of NO was decreased in the patients with renal hypertension. 3. Plasma level of ET-1 was higher, and plasma level of NO was lower in the patients with renal function damage than that of those without renal function damage. 4. BP, BUN and Scr were positively correlated with plasma ET-1, but they were negatively correlated with plasma concentration of NO.
Conclusion:
Plasma ET-1 and NO may play an important role in pathogenesis of renal hypertension; the change of their levels may be related to the progress of these renal diseases.
Related Concept Videos
Hypertension and Regulation of Blood Pressure
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Hypertension II: Pathophysiology
Hypertension III: Clinical Manifestations and Diagnostic Studies
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration
Serum Studies: Renal Function Tests

