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[Changes of left ventricular diastolic function in hypertensive patients with left atrial enlargement]
1Department of Internal Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Insights
Left atrial enlargement and diastolic dysfunction are early signs of hypertensive heart disease. This study found abnormal left ventricular diastolic function in hypertensive patients with left atrial enlargement.
Area of Science:
- Cardiology
- Hypertension Research
- Cardiac Imaging
Background:
- Hypertension can lead to cardiac structural and functional changes.
- Left ventricular diastolic dysfunction is a known complication of hypertension.
- The role of left atrial enlargement as an early indicator requires further investigation.
Purpose of the Study:
- To investigate the relationship between left atrial enlargement and left ventricular diastolic function in hypertensive patients.
- To identify early signs of hypertensive heart disease.
Main Methods:
- Radionuclide ventriculography was performed on 45 hypertensive patients.
- Patients were categorized into groups based on left atrial size and left ventricular mass index.
- A control group of 28 healthy subjects was included for comparison.
Main Results:
- Hypertensive patients with normal left atria showed normal left ventricular diastolic function.
- Hypertensive patients with left atrial enlargement exhibited abnormal left ventricular diastolic function.
- Left ventricular mass index was normal in all hypertensive patients studied.
Conclusions:
- Left atrial enlargement is associated with impaired left ventricular diastolic function in hypertension.
- Both left atrial enlargement and left ventricular diastolic dysfunction may serve as early indicators of hypertensive heart disease.
Abstract:
In order to find out the relationship between the left atrial enlargement and left ventricular diastolic function in hypertension, radionuclide ventriculography was performed in 45 hypertensive patients with normal left ventricular mass index(LVMI), including 23 with normal left atrium(Group I), 22 with left atrial enlargement(Group II), and 28 matched subjects as control(Group III). The results showed that the left ventricular diastolic function in Group I was normal, but abnormal in Group II. It is considered that left atrial enlargement and left ventricular diastolic dysfunction are the early signs of the hypertensive heart disease.