[Review on transforming growth factor beta and repair of tissue injury]
1Department of Plastic Surgery, Shanghai 9th People's Hospital, Shanghai Second Medical University, Shanghai, P. R. China 200011.
Objective:
To review the progress of the relation between transforming growth factor beta (TGF-beta) and repair of tissue injury.
Methods:
The recent articles about TGF-beta and tissue reconstruction were extensively reviewed. The gene identification, production, activation of TGF-beta and its role in the repair course of tissue injury were investigated.
Results:
TGF-beta belongs to a family of multifunctional polypeptides, its gene structure is highly conservative. Many animal models about TGF-beta and tissue injury have been established. The research mainly focuses on the classification, distribution of TGF-beta receptors and their signal pathway.
Conclusion:
TGF-beta plays an important roles in the regulation of repair of tissue injury.
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