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Updated: Aug 9, 2026

Mammary Transplantation of Stromal Cells and Carcinoma Cells in C57BL/6J Mice
Published on: August 12, 2011
[SV40 and cell immortalization]
1Department of Orthopedic Surgery, First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, P. R. China 610041.
Objective:
To explore the SV40-mediated immortalization, the related factors and their roles in cell immortalization.
Methods:
The original articles about cell immortalization and replicative senescence in recent decade were reviewed.
Results:
Cell immortalization was a multifaceted phenomenon, it was involved in viral DNA integration, activation of telomerase, inactivation of growth suppressors, and so on, and their roles were closely related.
Conclusion:
The research on cell immortalization may be expected to provide important insights into a broad range of cellular biological phenomenon, and the immortalized cells can play important roles in the research of cell engineering and tissue engineering as standard cells.
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