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[Development of biodegradable polymer scaffolds for bone tissue engineering]
1Department of Traumatology and Orthopedics, Nanfang Hospital, First Military Medical University, Guangzhou, Guangdong, P. R. China 510515.
Objective:
To investigate the selection and manufacture of ideal extracellular matrix materials in bone tissue engineering.
Methods:
The recent literatures about biodegradable polymers served as culture scaffolds of osteoblasts were widely reviewed, the advantages and disadvantages of biodegradable synthetic polymers and natural polymers were analysed.
Results:
The ideal extracellular matrix material in bone tissue engineering should be made up of inorganic materials, synthetic polymers and natural polymers, which possesses morphological structure of three-dimensional foam with self-mediated drug slow delivery system of bone growth factors.
Conclusion:
The design and manufacture of combined extracellular matrix materials in bone tissue engineering is a very important and urgent challenge.