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The colorectal adenoma-carcinoma sequence
A Leslie1, F A Carey, N R Pratt
1Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital, Dundee, UK. a.leslie@dundee.ac.uk
The British Journal of Surgery
|June 26, 2002
Summary
The adenoma-carcinoma sequence is strongly supported by recent evidence, particularly molecular genetic data. Further research is needed to understand genetic interrelationships and clinical applications for colorectal cancer management.
Area of Science:
- Oncology
- Gastroenterology
- Molecular Biology
Background:
- The adenoma-carcinoma sequence is the established model for colorectal cancer development.
- Recent evidence has significantly strengthened this hypothesis.
- Understanding this sequence is crucial for clinical practice.
Purpose of the Study:
- To critically review the evidence supporting the adenoma-carcinoma sequence.
- To highlight the clinical significance of this pathway.
- To identify gaps in current knowledge.
Main Methods:
- Comprehensive Medline searches for recent key articles.
- Manual scanning of reference lists from identified papers.
- Review of epidemiological, clinicopathological, and genetic data.
Main Results:
- Epidemiological, clinicopathological, and genetic evidence consistently support the adenoma-carcinoma sequence.
- Molecular genetic events and their cellular effects form the largest recent data set.
- Cytogenetics, molecular cytogenetics, and cytometry have provided valuable insights.
Conclusions:
- Current research continues to validate the adenoma-carcinoma sequence.
- More data is required on the interplay between different genetic mutations.
- The clinical utility of these findings requires further realization, with potential for genetic analysis in adenoma management.