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In vitro systems for tissue engineering.

W T Godbey1, Anthony Atala

  • 1Laboratory for Tissue Engineering, Harvard Medical School/The Children's Hospital, 300 Longwood Avenue, Bldg. #461, Boston, MA 02115, USA.

Annals of the New York Academy of Sciences
|June 26, 2002
PubMed
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This review explores in vitro tissue engineering systems, including bioreactors and gene delivery, for clinical applications. It highlights how cells, biomaterials, and incubation conditions are crucial for regenerative medicine strategies.

Area of Science:

  • Tissue Engineering
  • Regenerative Medicine
  • Biomaterials Science
  • Cell Biology
  • Gene Therapy

Background:

  • Tissue engineering integrates diverse scientific disciplines to create biological substitutes for tissue repair and regeneration.
  • Two primary approaches exist: in vitro tissue engineering (cell manipulation outside the body) and in vivo tissue engineering (utilizing the body's regenerative capacity with biomaterials).

Purpose of the Study:

  • To review key systems and components integral to in vitro tissue engineering.
  • To emphasize research directly applicable to treating clinical conditions.
  • To discuss the role of gene delivery in enhancing engineered cell function.

Main Methods:

  • Review of literature focusing on in vitro tissue engineering systems.

Related Experiment Videos

  • Analysis of components including bioreactors, cell-seeded constructs, and cell encapsulation.
  • Examination of gene delivery strategies for cellular control and function.

    • Main Results:

    • Identified critical roles of cells, biomaterials, and controlled incubation environments in in vitro systems.
    • Highlighted the significance of gene delivery for modulating cell behavior both in vitro and post-implantation.
    • Focused on studies with direct relevance to clinical translation in regenerative medicine.

    Conclusions:

    • In vitro tissue engineering systems, encompassing bioreactors, cell constructs, and gene delivery, are vital for developing clinical therapies.
    • Optimizing these components is essential for successful tissue regeneration and the treatment of various medical conditions.