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Accelerated and improved osteointegration of implants biocoated with bone morphogenetic protein 2 (BMP-2)
1Institute of Physiological Chemistry, University of Essen, Hufelandstrasse 55, D-45122 Essen, Germany. hp.jennissen@uni-essen.de
Annals of the New York Academy of Sciences
|June 26, 2002
Abstract:
A concept and methodology are presented for the direct biocoating of implantable metals like titanium and stainless steel with bone morphogenetic protein 2 (BMP-2) for future applications as cementless bone or dental prostheses. Such bioactive surfaces can influence cells and tissues by chemotactic as well as juxtacrine mechanisms. Reference is made to first experiments in sheep and rabbits in which BMP-2 coatings impressively increased the osteoinductive potential of titanium implants.