Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular signaling in bioengineered tissue microenvironments.

Donald P Bottaro1, Andrea Liebmann-Vinson, Mohammad A Heidaran

  • 1EntreMed, Inc., 9640 Medical Center Drive, Rockville, MD 20850, USA. donb@entremed.com

Annals of the New York Academy of Sciences
|June 26, 2002
PubMed
Summary

The extracellular matrix (ECM) provides structural support and signaling cues for cells. Tissue scaffolds, artificial ECMs, are crucial for tissue engineering and repair by guiding cell behavior.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiplex immunofluorescence microscopy assays for pharmacodynamic assessment of MET tyrosine kinase activation in the plasma membrane and nucleus.

PloS one·2026
Same author

Final Results From a Phase I Trial and Expansion Cohorts of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced/Metastatic Genitourinary Tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2024
Same author

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Cell reports·2024
Same author

Rilotumumab Resistance Acquired by Intracrine Hepatocyte Growth Factor Signaling.

Cancers·2023
Same author

Regression of Human Breast Carcinoma in Nude Mice after Ad<i>sflt</i> Gene Therapy Is Mediated by Tumor Vascular Endothelial Cell Apoptosis.

Cancers·2022
Same author

Correction: Phase II Study Evaluating 2 Dosing Schedules of Oral Foretinib (GSK1363089), cMET/VEGFR2 Inhibitor, in Patients with Metastatic Gastric Cancer.

PloS one·2022

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • Biological tissues and organs feature specialized cells within an extracellular matrix (ECM).
  • ECM composition dictates tissue properties (e.g., bone rigidity, skin elasticity) and regulates cell functions.
  • The ECM acts as a signaling reservoir, influencing cell migration, proliferation, and differentiation during development and repair.

Purpose of the Study:

  • To explore the role of the extracellular matrix (ECM) in tissue structure and function.
  • To investigate the application of artificial ECMs (tissue scaffolds) in tissue engineering and repair.
  • To understand how artificial microenvironments influence cell behavior for regenerative medicine.

Main Methods:

  • Review of ECM composition and its impact on diverse tissue types.

Related Experiment Videos

  • Analysis of natural and synthetic polymer-based tissue scaffolds.
  • Examination of cell behavior (pluripotent stem cells, progenitor cells) within artificial microenvironments.

    • Main Results:

    • ECM diversity significantly contributes to organ and tissue-specific properties.
    • Tissue scaffolds, alone or with cells/factors, successfully induce tissue formation and repair.
    • Study of cells in artificial niches identifies key signaling pathways for controlled proliferation and differentiation.

    Conclusions:

    • The extracellular matrix (ECM) is fundamental to tissue structure, function, and dynamic cellular regulation.
    • Tissue scaffolds represent a promising strategy for regenerative medicine, leveraging ECM principles.
    • Understanding cell-matrix interactions in engineered environments is key to advancing tissue repair and engineering.