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Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in

Mark A Fisher1, Bonnie B Plikaytis, Thomas M Shinnick

  • 1Program in Microbiology and Molecular Genetics, Emory University, Atlanta, Georgia 30322, USA.

Journal of Bacteriology
|June 26, 2002
PubMed

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Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...