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Antibiotic susceptibility pattern of Salmonella worthington isolated from neonates--a retrospective study

Dnyaneshwari P Ghadage1, Abhijit M Bal

  • 1Department of Microbiology, B.J. Medical College, Pune 411001, India.

Japanese Journal of Infectious Diseases
|June 26, 2002
PubMed

Insights

Salmonella worthington causes neonatal meningitis and septicemia. Fluoroquinolones like ciprofloxacin are effective treatments, as many strains resist common antibiotics.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Neonatal Care

Background:

  • Salmonella worthington is an emerging pathogen causing neonatal meningitis and septicemia.
  • A 5-year study isolated 30 S. worthington strains from neonates with septicemia, with or without meningitis.

Purpose of the Study:

  • To investigate the antibiotic resistance patterns of Salmonella worthington strains isolated from neonates.
  • To determine effective antibiotic therapies for S. worthington infections in newborns.

Main Methods:

  • Isolation and identification of Salmonella worthington from blood and cerebrospinal fluid.
  • Antimicrobial susceptibility testing of isolated strains against various antibiotics.

Main Results:

  • Most S. worthington strains showed resistance to penicillin and cefotaxime.
  • High resistance rates were observed for amikacin (60%) and chloramphenicol (86%).
  • No resistance was found against ciprofloxacin or norfloxacin.

Conclusions:

  • Parenteral fluoroquinolones, such as ciprofloxacin, are recommended for treating neonatal meningitis caused by S. worthington.
  • Antibiotic stewardship is crucial due to emerging resistance patterns in this pathogen.

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