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[Melatonin treatment of sleep disorders in disabled children]
Kjersti Ramstad1, Jon Håvard Loge
1Seksjon for habilitering Barneavdelingen Akershus universitetssykehus Postboks 42 1474 Nordbyhagen. kjersti_ramstad@hotmail.com
Insights
Melatonin effectively treats chronic sleep-wake cycle disorders in disabled children, improving circadian rhythm. Further research is needed on long-term effects and side effects.
Area of Science:
- Pediatric Neurology
- Sleep Medicine
- Developmental Disabilities
Context:
- Chronic sleep-wake cycle disorders are prevalent in developmentally and neurologically disabled children.
- These disorders often resist conventional hypnotic and psychotropic medications.
Purpose:
- To evaluate the efficacy of melatonin in treating sleep-wake cycle disorders in disabled children.
- To review existing literature and present clinical experience with melatonin treatment.
Summary:
- A literature search identified 75 articles, with 33 focusing on disabled children, generally indicating melatonin improves sleep-wake disorders.
- Clinical observations in 15 children showed positive effects in 13, aligning with literature findings.
- Current research highlights melatonin's benefits but notes limitations in understanding side effects and long-term outcomes.
Impact:
- Melatonin shows promise as a treatment for sleep disturbances in this vulnerable population.
- Provides practical suggestions for melatonin use in disabled children.
- Highlights the need for further controlled studies on safety and efficacy.
Background:
There is a high prevalence of chronic sleep-wake cycle disorders in developmentally and neurologically disabled children. Such disorders are often resistant to hypnotic and psychotropic drugs. Administration of exogenous melatonin can have an effect upon the circadian rhythm and establish a normal sleep-wake cycle.
Material And Methods:
Medline, Premedline and EBM Reviews were searched for articles on melatonin treatment of sleep-wake cycle disorders in children. Additionally, sleep was registered systematically in 15 developmentally or neurologically disabled children treated with melatonin.
Results And Interpretation:
The search identified 75 articles of which 33 included neurologically or developmentally disabled children. Reported results generally indicate that melatonin improves sleep-wake cycle disorders in these children. However, the majority of studies were open, and knowledge about side effects and long-term effects is limited. Our own experience is in accordance with the literature; melatonin had positive effects in 13 children. Suggestions for practical use of melatonin in disabled children are presented.
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