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Immunological functions of the proteasome
1Max Planck Institute of Immunobiology, Stübeweg 51, 79108 Freiburg, Germany.
Current Topics in Microbiology and Immunology
|June 27, 2002
Abstract:
Proteasomes are highly abundant cytosolic and nuclear protease complexes that degrade most intracellular proteins in higher eukaryotes and appear to play a major role in the cytosolic steps of MHC class I antigen processing. This review summarizes the knowledge of the role of proteasomes in antigen processing and the impact of proteasomal proteolysis on T cell-mediated immunity.