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Related Experiment Videos

Validation studies and proficiency testing.

Elke Ankilam1, Petra Heinze, Simon Kay

  • 1European Commission, Joint Research Centre, Food Products Unit, Ispra, Italy. elke.anklam@jrc.it

Journal of AOAC International
|June 27, 2002
PubMed
Summary
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Internationally validated methods are crucial for genetically modified organism (GMO) testing in Europe. Further validation, particularly for quantitative polymerase chain reaction (qPCR) methods, is needed to meet evolving demands for GMO analysis in diverse food matrices.

Area of Science:

  • Food Science
  • Biotechnology
  • Analytical Chemistry

Background:

  • Genetically modified organisms (GMOs) have been present in the European food market since 1996.
  • Current EU legislation mandates labeling for food products containing over 0.9% GMO content per ingredient.
  • There is a critical need for internationally validated reference methods to ensure confidence and compliance in GMO testing.

Purpose of the Study:

  • To highlight the necessity of internationally validated methods for GMO detection and quantification.
  • To review the current status of validation trials for GMO testing methodologies.
  • To identify areas requiring further research and validation, particularly for novel GMOs and diverse food matrices.

Main Methods:

  • Review of existing international validation trials for GMO detection methods.

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  • Assessment of current approaches for different food matrices.
  • Identification of needs for further validation studies, focusing on quantitative polymerase chain reaction (qPCR) methods.

    • Main Results:

    • Several GMO detection methods have undergone international validation, with existing approaches suitable for various circumstances and food matrices.
    • The requirement for formal method validation is widely accepted, with active involvement from national and international bodies.
    • Ongoing validation efforts are crucial to address the increasing demand for testing new GMOs and complex food backgrounds.

    Conclusions:

    • Internationally validated methods are essential for reliable GMO testing and regulatory enforcement in the European food supply chain.
    • Further validation studies, especially for qPCR techniques, are imperative to keep pace with the development of new GMOs and extraction methods.
    • Continued international collaboration is vital to establish robust reference methods for GMO analysis.