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Related Concept Videos

Buffer Effectiveness02:19

Buffer Effectiveness

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Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
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Framing Effects03:26

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Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
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Hybridoma Technology01:31

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
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Biological Effects of Radiation02:59

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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

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Health Information Technology (HIT)
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Frustration and Conflict: Approach-Approach, Approach-Avoidance

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Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
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Related Experiment Video

Updated: Feb 8, 2026

High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping
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BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping.

Arnold Oliphant1, David L Barker, John R Stuelpnagel

  • 1Illumina, San Diego, CA 92121-1975, USA. aoliphant@illumina.com

Biotechniques
|June 27, 2002
PubMed
Summary
This summary is machine-generated.

Illumina developed a cost-effective genotyping system for analyzing human genetic diversity. This high-throughput technology enables personalized medicine through accurate, large-scale SNP analysis.

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Area of Science:

  • Genomics
  • Biotechnology
  • Personalized Medicine

Background:

  • The Human Genome Project necessitates high-throughput, cost-effective analysis of human genetic diversity.
  • Personalized medicine relies on understanding genetic variations.

Purpose of the Study:

  • To introduce Illumina's genotyping system for cost-effective, high-throughput human genetic diversity analysis.
  • To meet the demands of genome-wide linkage disequilibrium studies.

Main Methods:

  • Utilized the BeadArray platform.
  • Implemented high multiplexing and modular, scalable automation.
  • Established a high-throughput genotyping service facility.

Main Results:

  • Achieved a capacity of one million single nucleotide polymorphism (SNP) assays per day.
  • Demonstrated high throughput, accuracy, and low cost per SNP.
  • Integrated quality scores for SNP call accuracy.

Conclusions:

  • The Illumina genotyping system supports personalized medicine by enabling efficient genetic diversity analysis.
  • The system is scalable and cost-effective for large-scale genomic studies.