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Sensitivity enhancement of DNA sensors by nanogold surface modification
Tao Liu1, Ji'an Tang, Long Jiang
1Laboratory of Colloid and Interface Science, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Science, Beijing 100080, People's Republic of China.
Biochemical and Biophysical Research Communications
|June 27, 2002
Abstract:
A novel amplified microgravimetric gene sensing system was developed using quartz crystal microbalance modified by gold nanoparticles anchored on its 1,6-hexanedithiol modified gold electrode surface, and ultrasensitive detection of DNA hybridization was accomplished at the level of at least 2 x 10(-16) M.