Cell-matrix interactions in cancer spreading--effect of aging

Passage of connective tissue barriers is a compulsory step in cancer spreading. This process involves a series of steps involving cell-matrix interactions. The complexity of these steps increased considerably during the last decades as a result of the identification of a large number of newly discovered macromolecular components of the extracellular matrix (ECM). It was also recognized that malignant cells can and do modify the production as well as the degradation of ECM components. The rapid development of aging biology during the second-half of the last century also contributed to the complexity but also to the importance of the newly emerging picture of cancer progression as a function of age. The structure and composition of the ECM is strongly age-dependent and may well represent one of the important factors influencing the age-distribution of human malignancies. As will be evident from the following reviews this relatively new and rapidly increasing picture of the age-dependence of cell-matrix interactions and cancer spreading should trigger more intense efforts on this relatively new discipline in cancer research.