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Drug target pharmacogenomics: an overview.
1Department of Pharmacy Practice, University of Florida, Gainesville, Florida 32610-0486, USA. johnson@cop.ufl.edu
American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice
|June 27, 2002
Summary
Pharmacogenomics studies genetic influences on drug response. A polygenic approach is needed to predict drug efficacy and toxicity, moving beyond single gene variations for clinical use.
Area of Science:
- Pharmacogenomics
- Genetics
- Drug Development
Background:
- Pharmacogenomics investigates genetic variations affecting drug efficacy and toxicity.
- Historically focused on drug metabolizing enzymes, now includes drug targets.
- Individualized medicine aims to optimize drug selection based on genetic makeup.
Purpose of the Study:
- To explore the role of genetic polymorphisms in drug targets on drug response.
- To address limitations of single-gene approaches in pharmacogenetics.
- To highlight the need for polygenic strategies in pharmacogenomics.
Main Methods:
- Review of literature on drug target polymorphisms and their association with drug effects.
- Analysis of limitations in current pharmacogenetic studies, such as single polymorphism predictability.
- Discussion of polygenic and genomic approaches for future pharmacogenomic research.
Main Results:
- Numerous associations exist between drug target polymorphisms and drug effects.
- Current data on drug target pharmacogenetics is not yet clinically actionable.
- Single polymorphism studies show limited predictive power and inconsistent results.
Conclusions:
- A polygenic or genomic approach is necessary to explain drug response variability.
- Pharmacogenomic strategies are being integrated into drug discovery and development.
- Pharmacogenomics holds significant potential for improving safe and effective medication use.