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Related Experiment Videos

Cough: potential pharmacological developments.

K F Chung1

  • 1National Heart & Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK. f.chung@ic.ac.uk

Expert Opinion on Investigational Drugs
|June 27, 2002
PubMed
Summary
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Persistent cough can stem from various conditions, and while opioids help, they cause side effects. Novel antitussive drugs targeting specific receptors offer potential for effective cough relief without adverse effects.

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Neuroscience

Background:

  • Cough is a common respiratory symptom, often transient after viral infections but persistent in conditions like asthma.
  • Current effective antitussives, primarily opioids, have significant side effects (drowsiness, constipation, dependence).
  • Understanding the cough reflex and sensitized cough mechanisms reveals potential therapeutic targets.

Purpose of the Study:

  • To review current understanding of cough reflex mechanisms.
  • To explore novel drug targets and agents for cough suppression.
  • To highlight the need for effective antitussives with improved safety profiles.

Main Methods:

  • Review of existing literature on cough reflex pathways.
  • Analysis of novel pharmacological targets including opioid and non-opioid receptors.

Related Experiment Videos

  • Examination of agents like receptor antagonists and channel modulators.

    • Main Results:

    • Opioids are effective but have dose-limiting side effects.
    • Novel targets include kappa- and delta-opioid receptors, nociceptin, neurokinin, bradykinin, and vanilloid receptors.
    • Agents like receptor antagonists and ion channel modulators show promise for inhibiting the cough reflex.

    Conclusions:

    • New therapeutic strategies targeting specific receptors and channels offer potential for novel antitussives.
    • These agents may act centrally, peripherally, or both.
    • Further clinical trials are necessary to evaluate the efficacy and safety of these novel compounds in humans.